Mapping the functional yeast ABC transporter interactome
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چکیده
منابع مشابه
Mapping the functional yeast ABC transporter interactome
ATP-binding cassette (ABC) transporters are a ubiquitous class of integral membrane proteins of immense clinical interest because of their strong association with human disease and pharmacology. To improve our understanding of these proteins, we used membrane yeast two-hybrid technology to map the protein interactome of all of the nonmitochondrial ABC transporters in the model organism Saccharo...
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Exposure of Saccharomyces cerevisiae to sorbic acid strongly induces two plasma membrane proteins, one of which is identified in this study as the ATP-binding cassette (ABC) transporter Pdr12. In the absence of weak acid stress, yeast cells grown at pH 7.0 express extremely low Pdr12 levels. However, sorbate treatment causes a dramatic induction of Pdr12 in the plasma membrane. Pdr12 is essenti...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2013
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1293